Forgive me if it already has one. I'm a blender n00b, and I find that its current interface is hard to use. A skinnable interface would easily allow n00bs like me to use a less complex version, while pros would still be able to have all the features they want. Also, if someone could make a skin that makes it behave like Maya... I love that interface (I've used Maya PLE), but I like the open-sourceness (and hence freeness) of blender...
You will always have problems adapting from one software to another because of the interface. I don't believe blender needs a new interface really... just needs to be cleaned up a bit. Once your used to blenders interface you can move quite a bit faster than in any others. I've still not got the hang of Maya but I like blenders interface over Max and Lightwave... though it looks like it borrows heavily from lightwave its quite a bit different. I would just suggest you plug away at it... that all thats really gonna get you used to it. Having a skinnable interface, in my opinion, would only slow the interface down. Maybe in version 3.... who knows... just my opinion.