Novice and advanced users will love the ability to customize their layout completely. From simply splitting their viewport, to fully customizing it with python scripting, Blender works for you.
Blender’s interface also offers:
Consistency across all platforms
No disruptive pop-up windows
Crisp text, including support for hi-dpi/retina displays.
Unlike Blender 2.7 (where most keys were already assigned), Blender 2.8 comes with a minimal keymap, giving you more room to assign new shortcuts to speed-up your workflow.
Custom preferences can be set per keymap for special actions such as selecting with left or right click, which action to perform with Spacebar, pie menus, and more.